Sophia's Story
Dan Lewis Foundation | Summer 2024

Every Traumatic Brain Injury story is different, and the outcome for individuals is often unpredictable



This is Sophia Augier's story

On February 26th, 2023, I glided over the freshly powdered slopes of Vermont as the flurries melted against my wind-burned cheeks. The twists and turns of the Rollercoaster Trail left me with an adrenaline high. Each jump I landed fed the thrill of the ride until I was suddenly consumed by darkness, and after the accident, my senior year turned into a nightmare. High school had gone exactly as planned. After years of hard work, late-night study sessions, and an activity-packed resume, I was set to attend the Massachusetts Institute of Technology (MIT) in the fall. My future was brighter than ever, but that single moment on the slopes left my future in jeopardy. Instead of celebrating my achievements, I was confined to a dark basement, stripped of social interaction, grappling with excruciating physical pain and overwhelming fear. Day after day, I sat there alone, trying to weed through the unknowns and search for a glimpse of hope. My dreams of MIT felt impossible as I struggled with memory loss, severe headaches, and an inability to read or even step outside.

As the days passed, the events of that fateful day slowly returned to me. The edge of my board clipped the snow so fast, sending me tumbling before I could react. When I regained consciousness, I was met with blood-stained snow through waves of darkness. Having lost control of my bladder, I found myself soaked to the bone and gasping for air as my face pressed against the snow. Despite this, I forced myself to get up and make it down the mountain. Embarrassed, I brushed off the incident and continued with my day. With the fresh snow the following morning, I ignored a nagging headache and returned to the slopes. It wasn't until the ride home that overwhelming nausea forced me to acknowledge something was wrong. Days later, my symptoms worsened, but they aligned with a typical flu rather than a traumatic brain injury. Initially misdiagnosed with mononucleosis by my physician, it took an emergency room visit to finally confirm my concussion. The unfortunate waiting period had consequently worsened my symptoms and prolonged my recovery. Finally, a specialist confirmed my worst fears. While the flu-like symptoms faded, my blurry vision, memory loss, and headaches persisted. The prospect of MIT seemed more distant than ever. Returning to school felt surreal; I could barely participate in classes. Watching my friends celebrate their college commitments, I felt like a kindergartner in a 12th-grader's body while I sat in a dimly lit corner, unsure if I'd ever think like myself again.


Months of vision therapy and rehabilitation followed. The drive and grit that fueled my academic success now drove my recovery. Slowly but surely, the darkness lifted, and I began to see a future again. My hard work paid off, and I regained the ability to pursue my dreams.


Today, I have just completed my first year at MIT. I joined the Division 1 crew team, worked for the MIT ambulance service and made lifelong friends. As I write this from my apartment in Cape Town, South Africa, where I'm conducting engineering research, I reflect on my journey.


My experience taught me that life's path is unpredictable. Adversity can strike at any moment, but it's how we respond that defines us. The pain and fear I endured were real, but they also revealed a resilience I didn't know I had. Embracing this resilience, I learned to navigate the unexpected and emerge into the strong woman I am today. In the grand scheme of life, our challenges are as much a part of our story as our achievements. My traumatic brain injury was a test of my strength and determination, and it reshaped my understanding of success. True success isn't just about reaching our goals; it's about finding the courage to keep going when those goals seem out of reach. My journey through concussion and recovery has been my greatest teacher, showing me that resilience, determination, and hope are the keys to navigating life's rollercoaster ride.


Sophia Augier

A man is holding a fish in his hand in front of a lake.
By Dan Lewis Foundation November 6, 2024
After a life-altering accident in October 2022, Devon Guffey’s story is about resilience and determination. His journey has been profiled in the summer 2023 issue of the Making Headway Newsletter: https://www.danlewisfoundation.org/devons-story . Hit by a drunk driver, Devon sustained severe brain and physical injuries, including axonal shearing, a traumatic frontal lobe injury, and facial fractures. Even after contracting meningitis while in a coma, Devon fought hard to survive – and today, his recovery continues to inspire us all. In late 2023, Devon worked as an assistant basketball coach at Blue River Valley, where he had once been a student. His love for sports and dedication to regaining his physical strength returned him to the gym, where his hard work paid off. Devon’s persistence earned him another job at the YMCA, guiding gym members and supporting facility upkeep. Through all the challenges—deafness in one ear, blindness in one eye, and a permanent loss of taste and smell—Devon perseveres. He recently regained his driving license, a significant milestone that symbolizes his increasing independence and cognitive and physical recovery. While each day may not show significant changes, Devon now sees his progress over time. Today, Devon speaks to groups about his journey, the dangers of drunk driving, and finding strength in adversity. His message is clear: recovery is a process, and sometimes, "can't" simply means "can't do it yet ." Every TBI is unique, and Devon’s story powerfully reminds us of the strength that comes from resilience and community. We are grateful to Devon for continuing to share his story and for his role in uplifting others facing difficult paths. His journey is a testament to the fact that we are stronger together. #BrainInjuryAwareness #DevonsJourney #Resilience #EndDrunkDriving #MakingHeadway
A close up of a brain with a lot of cells and a purple background.
By Dan Lewis Foundation | Summer 2024 July 10, 2024
Scientists worldwide are working to find ways to stimulate healing and functional recovery after severe brain injuries. This work is driven by the desperate needs of persons who have suffered brain damage. It is inspired by the knowledge that the information required to create new brain cells, cause these cells to interconnect, and stimulate new learning is contained in our genome. Now that we can readily generate stem cells from adult tissue, we have access to the genomic program that can control all of the intricate details of brain tissue formation. A number of different research themes are being pursued productively. These include: (1) enabling injured neurons to self-repair (“axonal repair”) 1,2 ; (2) replacing damaged tissue by increasing the growth of new neurons (“neurogenesis”) 3-5 ; (3) transplanting new brain cells that are derived from a person’s own stem cells (“autologous cellular repletion”) 6-8 ; (4) stimulating the re-wiring of new or surviving tissue by encouraging the formation of new connections (“synaptogenesis”) 9,10 ; and (5) augmenting the function of a damaged brain by the use of bio-computational prostheses (“brain-computer interfaces”) 11,12 ; We’ve explored these themes in previous newsletters. The goal of stimulating meaningful brain regeneration is now sufficiently plausible that a large-scale, well-funded campaign needs to be funded to bring meaningful new therapies to patients within the foreseeable future. Here, we suggest a high-level outline of the research themes for such a campaign. A ‘moon shot’ program towards brain regeneration would leverage cutting-edge technologies in stem cell research, gene therapy, synaptic plasticity, neuronal repair, and brain-computer interfaces (BCIs) to develop innovative treatments for brain injuries and neurodegenerative diseases. These treatments would target the restoration of lost brain functions and improvement in the quality of life for individuals affected by severe brain injuries. This research agenda aims to catalyze serious discussion about creating a federal program with funding, organizational resources, and expert governance to enable brain regeneration in our lifetimes. Major Themes For a Brain Regeneration “Moon Shot” Program 1: Promote the formation of new neurons 1.1 Stimulate the brain to create new neurons 1.2 Create new neurons from patient-derived induced pluripotent stem cells to be transplanted back into the patient. Create new glial cells to support neurogenesis. 2: Stimulate new synaptic formation 2.1 Develop drugs that enhance synaptic plasticity and promote the formation of new synaptic connections 3: Stimulate self-repair of damaged neurons 3.1 Develop drugs that de-repress neurons and, thereby, enable axonal regrowth 4: Develop brain-computer interfaces (BCIs) for brain-injured patients 4.1: Develop and test BCIs that enable the brain to control behaviors or external devices and, thereby, augment or replace impaired functions. 4.2: Develop and test BCIs that can accelerate the training of remapped brain tissue in persons with brain injuries to optimize functional recovery. 4.3: Combine BCIs with other strategies (e.g., cell repletion, synaptogenesis, and enhanced plasticity) to accelerate adaptation and functional improvement. The proposed research themes can underpin targeted research to stimulate meaningful brain regeneration, offering new hope for patients with brain injuries and neurodegenerative diseases. While the scientific challenges are profound, there has been sufficient progress to justify substantial investment in brain regeneration research. Any such large-scale program will require coordinated collaborations among academic and commercial partners, skillful governance and management, and a shared sense of profound commitment to the goal. The recent pace of advances in cell biology, stem cell technology, bio-computational interfaces, and genomically targeting medicines suggests that large-scale investment will yield meaningful clinical advances toward brain regeneration after injury. With robust funding and skilled leadership, this comprehensive research agenda has a realistic potential to transform scientific breakthroughs into tangible medical therapies, offering hope to millions affected by brain damage.
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