Devon’s Story
Dan Lewis Foundation | Fall 2023

On October 7, 2022, I was nineteen years old and out with four friends for what we all thought would be a fun evening of partying with friends. Our group was about 20 seconds from arriving at the party when a teenage drunk driver hit us head-on in Indiana. The drunk driver’s alcohol level was more than twice the legal limit. I was the most critically injured of the group, suffering massive life-threatening head injuries and bleeding from my head that emergency medical technicians could not stop. Taken to the local hospital, it quickly became apparent that my life hung in the balance, and survival would hinge on transferring me to a major trauma center. I was quickly life-lined by helicopter to Indiana University Methodist Hospital, one of only four level-one trauma centers in the state, to treat my traumatic brain injuries (TBI). My family learned it was unlikely I would survive. For a month, I remained in a coma. I had broken multiple bones on my face and had two major brain injuries: severe axonal shearing and a frontal lobe injury. Axonal shearing occurs when the brain shifts rapidly inside the skull, and long fibers in the brain (axons) scrape against the skull’s hard bone, causing traumatic brain injury. Axonal shearing often results in a coma and can impact multiple brain areas, as in my case. My frontal lobe injury is often associated with muscle weakness on one side of the body, depression, memory, and attention problems, all experiences I had. While still in a coma, two weeks after admission to Methodist Hospital, I contracted meningitis, complicating my recovery. While I had no memory of the week before and for weeks after, I slowly regained consciousness. Once stabilized, I was transferred to the rehabilitation unit at the Rehabilitation Hospital of Indiana (RHI), where I remained for another month. At that time, I was wheelchair-bound, and it was unclear if I would ever walk again or regain my memory and attention skills. 

Before my accident, I secured a car salesman job at Ray Skillman in Indiana. I felt the job was a good fit and thought I had a promising career working as a car salesman. Outside of work, I always considered myself a serious athlete; I loved playing basketball, working out in the gym, and fishing as often as possible. My determination, fitness, and “athlete mentality” contributed to my survival and recovery. While my recovery, as viewed by my doctors, is nothing less than miraculous, I still have multiple residual problems that may or may not be resolved through therapy. As a result of the accident, I am deaf in my right ear, blind in my left eye, have right-sided tremors, poor balance, and periods of extreme cold chills even in hot weather.  One of the most serious challenges I faced as I began my recovery was the emotional turmoil and depression I experienced. I felt furious with friends and family when they tried to stop me from attempting activities I thought I could do. Eventually, I made peace with the problem when I realized those who cared most about me struggled with the “new” Devon. I gradually understood they were struggling too, and their concern that I “shouldn’t do” certain things was their way of showing they cared. I continue to attend group therapy with those who have also experienced TBI. Despite the challenges ahead, I am grateful for my recovery so far and hope to return to selling cars and playing basketball, goals that I believe are within reach. My doctors have told me that my attention and memory, two areas they would not have expected the degree of recovery I have achieved, are impressive and continue to improve.

I think that there are several positive outcomes from the accident. First, I hope to be able to share my fight for recovery with young people who have experienced similar problems. Next, I want to make others aware of the dangers of drunk driving. And finally, I believe I am a kinder, gentler person willing to reach out and support others dealing with complex problems. I believe God reached out and has a plan for me. 


Editor’s Note: Devon recently received notification that he was a nominee for patient of the year at the Rehabilitation Institute of Indiana. On September 18, 2023 Devon was chosen as Patient of the Year. We wish Devon all the best as he continues his journey towards recovery.

A man is holding a fish in his hand in front of a lake.
By Dan Lewis Foundation November 6, 2024
After a life-altering accident in October 2022, Devon Guffey’s story is about resilience and determination. His journey has been profiled in the summer 2023 issue of the Making Headway Newsletter: https://www.danlewisfoundation.org/devons-story . Hit by a drunk driver, Devon sustained severe brain and physical injuries, including axonal shearing, a traumatic frontal lobe injury, and facial fractures. Even after contracting meningitis while in a coma, Devon fought hard to survive – and today, his recovery continues to inspire us all. In late 2023, Devon worked as an assistant basketball coach at Blue River Valley, where he had once been a student. His love for sports and dedication to regaining his physical strength returned him to the gym, where his hard work paid off. Devon’s persistence earned him another job at the YMCA, guiding gym members and supporting facility upkeep. Through all the challenges—deafness in one ear, blindness in one eye, and a permanent loss of taste and smell—Devon perseveres. He recently regained his driving license, a significant milestone that symbolizes his increasing independence and cognitive and physical recovery. While each day may not show significant changes, Devon now sees his progress over time. Today, Devon speaks to groups about his journey, the dangers of drunk driving, and finding strength in adversity. His message is clear: recovery is a process, and sometimes, "can't" simply means "can't do it yet ." Every TBI is unique, and Devon’s story powerfully reminds us of the strength that comes from resilience and community. We are grateful to Devon for continuing to share his story and for his role in uplifting others facing difficult paths. His journey is a testament to the fact that we are stronger together. #BrainInjuryAwareness #DevonsJourney #Resilience #EndDrunkDriving #MakingHeadway
A close up of a brain with a lot of cells and a purple background.
By Dan Lewis Foundation | Summer 2024 July 10, 2024
Scientists worldwide are working to find ways to stimulate healing and functional recovery after severe brain injuries. This work is driven by the desperate needs of persons who have suffered brain damage. It is inspired by the knowledge that the information required to create new brain cells, cause these cells to interconnect, and stimulate new learning is contained in our genome. Now that we can readily generate stem cells from adult tissue, we have access to the genomic program that can control all of the intricate details of brain tissue formation. A number of different research themes are being pursued productively. These include: (1) enabling injured neurons to self-repair (“axonal repair”) 1,2 ; (2) replacing damaged tissue by increasing the growth of new neurons (“neurogenesis”) 3-5 ; (3) transplanting new brain cells that are derived from a person’s own stem cells (“autologous cellular repletion”) 6-8 ; (4) stimulating the re-wiring of new or surviving tissue by encouraging the formation of new connections (“synaptogenesis”) 9,10 ; and (5) augmenting the function of a damaged brain by the use of bio-computational prostheses (“brain-computer interfaces”) 11,12 ; We’ve explored these themes in previous newsletters. The goal of stimulating meaningful brain regeneration is now sufficiently plausible that a large-scale, well-funded campaign needs to be funded to bring meaningful new therapies to patients within the foreseeable future. Here, we suggest a high-level outline of the research themes for such a campaign. A ‘moon shot’ program towards brain regeneration would leverage cutting-edge technologies in stem cell research, gene therapy, synaptic plasticity, neuronal repair, and brain-computer interfaces (BCIs) to develop innovative treatments for brain injuries and neurodegenerative diseases. These treatments would target the restoration of lost brain functions and improvement in the quality of life for individuals affected by severe brain injuries. This research agenda aims to catalyze serious discussion about creating a federal program with funding, organizational resources, and expert governance to enable brain regeneration in our lifetimes. Major Themes For a Brain Regeneration “Moon Shot” Program 1: Promote the formation of new neurons 1.1 Stimulate the brain to create new neurons 1.2 Create new neurons from patient-derived induced pluripotent stem cells to be transplanted back into the patient. Create new glial cells to support neurogenesis. 2: Stimulate new synaptic formation 2.1 Develop drugs that enhance synaptic plasticity and promote the formation of new synaptic connections 3: Stimulate self-repair of damaged neurons 3.1 Develop drugs that de-repress neurons and, thereby, enable axonal regrowth 4: Develop brain-computer interfaces (BCIs) for brain-injured patients 4.1: Develop and test BCIs that enable the brain to control behaviors or external devices and, thereby, augment or replace impaired functions. 4.2: Develop and test BCIs that can accelerate the training of remapped brain tissue in persons with brain injuries to optimize functional recovery. 4.3: Combine BCIs with other strategies (e.g., cell repletion, synaptogenesis, and enhanced plasticity) to accelerate adaptation and functional improvement. The proposed research themes can underpin targeted research to stimulate meaningful brain regeneration, offering new hope for patients with brain injuries and neurodegenerative diseases. While the scientific challenges are profound, there has been sufficient progress to justify substantial investment in brain regeneration research. Any such large-scale program will require coordinated collaborations among academic and commercial partners, skillful governance and management, and a shared sense of profound commitment to the goal. The recent pace of advances in cell biology, stem cell technology, bio-computational interfaces, and genomically targeting medicines suggests that large-scale investment will yield meaningful clinical advances toward brain regeneration after injury. With robust funding and skilled leadership, this comprehensive research agenda has a realistic potential to transform scientific breakthroughs into tangible medical therapies, offering hope to millions affected by brain damage.
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